Safety was assessed by detecting leakage of hydrogen peroxide using a hand-held detector. Efficacy was tested using 4- and 6-log Geobacillus stearothermophilus biological indicators (BIs) and in-house prepared test discs containing approximately 10(6) meticillin-resistant Staphylococcus aureus (MRSA), Clostridium difficile and Acinetobacter baumannii. To compare the efficacy, efficiency and safety of hydrogen peroxide vapour (HPV Clarus R, Bioquell, Andover, U.K.) and aerosolized hydrogen peroxide (aHP SR2, Sterinis, now supplied as Glosair, Advanced Sterilization Products (ASP), Johnson & Johnson Medical Ltd, Wokingham, U.K.) room disinfection systems. This was a head-to-head comparison of two hydrogen- peroxide-based room decontamination systems. New catalysts, multifunctional surfactants, self- decontaminating materials and corrosion preventing technologies should be developed before peroxide-based decontaminants really become true "green" decontaminants.Įfficacy, efficiency and safety aspects of hydrogen peroxide vapour and aerosolized hydrogen peroxide room disinfection systems. More study on the mechanisms of peroxide-based decontaminants and the interfacial interactions in heterogeneous decontamination media is suggested. For example, their decontamination efficiencies are not as high as those of chlorine-containing decontaminants, and some peroxide-based decontaminants show relatively poor effect against certain agents. However, currently available peroxide-based decontaminants still have some deficiencies. Recent research advances in alpha-nucleophilic/oxidative reaction mechanisms of peroxide-based decontamination against chemical warfare agents were reviewed, and some classical peroxide-based decontaminants such as aqueous decontaminating solution, decontaminating foam, decontaminating emulsions, decontaminating gels, decontaminating vapors, and some newly developed decontaminating media (e.g., peroxide-based self- decontaminating materials and heterogeneous nano-catalytic decontamination systems) were introduced. These technologies have been applied in countering chemical/biological terrorist attacks, dealing with chemical/biological disasters and destructing environmental pollutants. With the boosting demand for eco-friendly decontaminants, great achievements in peroxide-based decontaminating technologies have been made in recent years.
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